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Home > Understanding Kidney Disease > Kidney Diseases > FSGS


FSGS Basic

Focal Segmental Glomerulosclerosis (or FSGS) is a relatively common form of kidney disease, especially in the US. It is a type of Glomerulonephritis, a disease in which scarring occurs inside some of the glomeruli, the tiny filters of the kidneys. The scarred glomeruli are no longer able to filter blood adequately.


This disorder affects both children and adults. Males and boys are affected slightly more often than females and girls, and it also occurs more often among African Americans. It is classified as either primary or secondary FSGS:

Primary form of this disease occurs spontaneously or without an identifiable cause;

Secondary type is links to a multitude of conditions that include drug abuse (painkillers, heroin), HIV, inherited genetic problems, obesity, reflux nephropathy, sickle cell disease, cancers, hypertension, and others.

Exams and Tests

• Conventional tests: urine test, blood test, and kidney biopsy.

• Immune special examination and diagnosis

- Kidney damage tests. Checking items include: UTP, U-malb, U-TRF, U-IGG, β 2-microglobulin, α1-microglobulin, α2-macroglobulin, κ light chain, λ light chain, U- NAG, U-GGT, and Uosm.

- Urinary protein electrophoresis.

- Selective urine protein index (SPI).

- Complement in blood serum test. This test include C3, C4, CH50, C3B, etc.

- Toxins in blood test. Checking items include: BUN, Creatinine, UA, β 2-microglobulin, Cyc C, RBP, HCY, and PTH.


Over 50% of people with this disease develop into Chronic Kidney Failure within 10 years. Fortunately, timely and effective treatment can help patients prevent renal failure. For information about the best treatment for you, feel free to Contact Us.

Kidney Transplant in FSGS

The risk of this disease returning in the transplanted kidney varies from 20-50%. The recurrence can happen within hours to days, though most cases will be within the first year after transplant.

More than half of patients with recurrent FSGS in their transplant will lost their kidney within 5 years. Hence, once the disease comes back to the new kidney, it is essential to get timely treatment and avoid transplanted kidney failure. Blood Pullotion Therapy is recommended.

If you would like to get more information or have any problem in managing your kidney disease, feel free to chat with our online doctor!

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FSGS Symptoms

unless progressive damage to the kidneys severely interferes with their normal function. In this case, people with the disease may experience symptoms as below.

• Foamy or frothy urine

This is due to excessive Protein in Urine. The glomeruli of the kidneys have responsibility of regulating protein levels in the urine. When the glomeruli become damaged or scarred, they are unable to prevent protein from leaving the body in the urine, proteinuria presents. When protein from the urine hits the toilet bowl after urination, foamy or frothy urine is produced.

• Swelling, or edema

Some patients with FSGS develop swelling (edema) of the eyelids in the morning and swollen of the legs, ankles, feet, hands, face or abdomen late in the day due to fluid retention.

• High Blood Pressure

Elevated blood pressure is often seen with primary FSGS. Many patients will have hypertension at the time of diagnosis.

• Poor Appetite

Loss of appetite may be result from buildup of toxins in the body due to kidney dysfunction of filtering toxic wastes, medicines, and diet changes.

• Fatigue

Fatigue in kidney disease is most often caused by anemia, a shortage of oxygen-carrying red blood cells.

• Weight gain

If the body retains water, rapid weight gain may be caused.

• Nausea and/or vomiting

With severely damaged kidney function, large amount of nitrogen will buildup in the blood and stimulate the gastrointestinal tract, resulting in nausea and/or vomiting.

Other signs and symptoms of FSGS may also include pain of back (flank and abdomen), low blood protein, high blood cholesterol level, fever and chill, etc. If you have some of the above discomforts, see your doctor to discuss what might be causing them and corresponding treatment. Or, feel free to Contact Us.

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FSGS Treatment

We have the expertise and experience to treat FSGS on all fronts. Using the latest, most advanced therapies for FSGS, we personalize your care to ensure the most advanced treatment with no side effect on your body. We offer the latest innovative kidney disease treatments that are only available in China.

Frequently, treatment for FSGS requires more than one type of therapy. We are recognized as a leader in customizing care for kidney disease, which often translates into positive results that might not be possible elsewhere.

If you or your beloved one has been diagnosed with FSGS, our kidney doctors will discuss the best treatment option. It depends on the severity of kidney damage. One or more of the therapies as below may be recommended to treat your kidney disease.

Blood Pollution Therapy

Blood Pollution Therapy is the latest treatment for FSGS. This is a systematic treatment which can only relieve the symptoms but also treat kidney disease from the root cause.

The treatment process include three processes: combined blood purification techniques to remove blood stasis, supply essential elements to the blood, and recover the kidney function.

Whether your condition is suitable to get Blood Pollution Therapy or not? Feel free to Contact Us for further guidance.


Immunotherapy is a personalized treatment which is conducted based on an accurate diagnosis. So, the treatment effect is satisfactory.

The whole treatment include six steps named an accurate diagnosis, inhibit excessive inflammatory response, immune tolerance, immune adjustment, immune protection, and immune clearance. Certain steps are selected according to your disease.

Micro-Chinese Medicine Osmotherapy

Different from traditional Chinese medicine, Micro-Chinese Medicine Osmotherapy is applied externally with no adverse effect to human body. It is a kind of natural herbal remedy.

Functions of this therapy include dilate blood vessels, anti-inflammation, anti-coagulation, and degrade harmful substances like immune complexes and extracellular matrix. Treatment effects can be seen soon within one week after getting this therapy. You can make an appointment with our renowned nephrologists to get yourself evaluated for this treatment.

Traditional Chinese Medicine

Traditional Chinese medicine (TCM) techniques such as acupuncture, herbal medicine, food therapy, qigong, cupping, etc can also be used as complementary treatment for your better recovery from FSGS.

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FSGS Diet﹠Fitness

Focal Segmental Glomerulosclerosis (FSGS) can lead to health complications and can be fatal if it progresses to Kidney Failure. A carefully planned diet and healthy living reduce the stress on the kidneys and help slow down the disease's deterioration. So, work with your nutritionist to develop a good plan for your situation or make an appointment with renowned nephrologists for personalized advice!

▪ Healthy diet. Maintaining a special diet helps decrease the load on the kidneys and also assists in the slowing down the further kidney damage. In general, the recommended diet include food items, that are controlled in protein, sodium, potassium, phosphorus levels. Specific dietary arrangement will depend on the extent of kidney damage. For the best diet in your situation, feel free to Contact Us.

▪ Regular exercise. This will help you feel better, stronger, and give you more energy. It is important to talk to your doctor about suitable exercise program. Most people with FSGS can benefits from certain type of activities, such as stretching, resistance exercises, and cardiovascular exercise. There are few risks as long as you do them properly and start slowly and gradually progressed.

▪ Don't use substances that may harm your kidneys like alcohol, any kind of tobacco, or illegal drugs. Also, be sure that your doctor knows about all prescription medications, over-the-counter medicines, and herb that you are taking.

▪ Lost weight if necessary. Keep a healthy weight can help you manage your blood glucose, control your blood pressure, and lower your risk for kidney disease complications. Talk to your doctor about how much you should weigh. If you are overweight, losing just a few pounds can make a big difference.

▪ Adjust your work. Kidney disease may affect your ability to do your currant job. For instance, your job may be too difficult or tiring. You may need to look at changes in your hours, job tasks, or the type of work you do. Many persons on dialysis or with transplants are employed, and there are a large number of jobs that are choices for those with FSGS.

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